Philadelphia, PA 215.561.9100

Villanova, PA 610.688.9100

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How Do Hyaluronic Acid Fillers Compare to Collagen Stimulators?

How do biostimulators differ from hyaluronic acid fillers? Our Philadelphia and Villanova-based team at Cross Medical Group knows that patients may not be sure which type of filler is best for their needs, especially if they are new to cosmetic treatments.

The first thing to know is that every decision will be made with guidance from an experienced injector at the practice, so don’t feel like you have to figure out which options is best for you on your own!

In the meantime, it can be good to know that fillers aren’t all equal and don’t all work the same way. There are several different types of filler, each with unique consistencies and designed for enhancing separate areas of the face.

The two main categories of injectable fillers are hyaluronic acid fillers and biostimulatory injections, which are also sometimes called collagen stimulators.

Here’s what you should know about how they compare: 

Hyaluronic Acid Fillers

The most popular facial filler collections—such as the Juvederm® family—contain hyaluronic acid as their primary ingredient. Hyaluronic acid is a naturally occurring molecule that provides lubrication to the skin, eyes, and other tissues of the body. It can retain 1,000 times its own weight in water. Many moisturizers and other topical skin care products contain hyaluronic acid, and the firmness and flexibility of hyaluronic acid products vary. Since they contain the same type of sugar molecule that’s found in the body, hyaluronic acid fillers are generally well-tolerated by the body and there’s a low risk of adverse reactions. These temporary fillers generally last for around six to 12 months—depending on the type that is used—and some last up to two years. Despite their longevity, the effects are technically reversible for patients who want to make a different choice after their treatment.


Biostimulators—such as Radiesse® and Sculptra® Aesthetic—contain materials other than hyaluronic acid as their primary ingredients. Although biostimulators provide some volume, their primary role is to promote collagen growth in the deeper layers of skin. These types of fillers generate results that are more gradual, longer lasting, and better for long-term smoothing of the face. They are also thicker and typically not good for smaller areas that require a softer, more lightweight filler, such as the lips. Biostimulators are often best for treating dramatic or extensive volume loss. Note that because they stimulate natural collagen production, biostimulators produce results that can’t be dissolved or reversed. The results generally last for 12 to 24 months or more. 

Ready for a consultation? Contact Cross Medical Group to arrange a visit. Call us at (215) 561-9100 or submit a contact form to set up a visit.


2200 Arch Street Suite 120, Philadelphia, PA 19103
Philadelphia, PA

2200 Arch Street Suite 120, Philadelphia, PA 19103
PH: 215.561.9100

775 E. Lancaster Avenue Suite 230, Villanova, PA 19085
Villanova, PA

775 E. Lancaster Avenue Suite 230, Villanova, PA 19085
PH: 610.688.9100



Cross Medical Group

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